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Qin, Lu-shan; Zhao, Hai-ping; Zhao, Yan-ling; Ma, Zhi-jiel; Zeng, Ling-na; Zhang, Ya-ming; Zhang, Ping; Yan, Dan; Bai, Zhao-fang; Li, Yue; Hao, Qing-xiu; Zhao, Kui-jun; Wang, Jia-bo; Xiao, Xiao-he

To compare the bidirectional effect of rhubarb total anthraquinone (TA) and total tannins (TT) on rats ' liver . One hundred rats were randomly divided into 10 groups, i.e., the blank group, the model group, the blank + high dose TA group, the blank +low dose TA group, the blank + high dose TT group, the blank + low dose TT group, the model + high dose TA group, the model + low dose TA group, the model +high dose TT group, and the model + low dose TT group, 10 in each group. The carbon tetrachloride (CCI4) was used to prepare the acute liver injury rat model. TA and TT of rhubarb (at 5.40 g crude drugs/kg and 14.69 g crude drugs/kg) were intragastrically administrated to rats in all groups except the blank group and the model group, once daily for 6 successive days.The general state of rats , biochemical indices such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), laminin (LN), hyaluronic acid (HA), transforming growth factor beta1 (TGF-beta1), as well pathological results of rat liver tissues. Finally the protection laws of TA and TT for rats ' liver were analyzed using factor analysis. Compared with the blank control group, all biochemical indices increased in the blank group (P < 0.05, P < 0.01). HA also increased in the blank + high dose TA group; AST, ALT, and HA also increased in the blank +high dose TT group (P < 0.05). Compared with the model group, AST, ALT, ALP, HA, and TGF-beta1 significantly decreased in the model + low dose TA group, the model + high dose TA group, the model + low dose TT group (P < 0.05, P < 0.01). Serum AST, ALT, and ALP also decreased in the model + high dose TT group (P < 0.05, P < 0.01). Pathological results showed that mild swollen liver cells in the model + high dose TA group. Fatty degeneration and fragmental necrosis around the central veins occurred in the blank + high dose TA group. The pathological injury was inproved in the model +low dose TA group. Two common factors, liver

Cafeteria feeding induces interleukin-1beta mRNA expression in rat liver and brain.

Hansen, M K; Taishi, P; Chen, Z; Krueger, J M


intake affects gut-immune function and can provide a strong intestinal antigen challenge resulting in activation of host defense mechanisms in the digestive system. Previously, we showed that feeding rats a cafeteria diet increases non-rapid eye movement sleep by a subdiaphragmatic mechanism. Food intake and sleep regulation and the immune system share the regulatory molecule interleukin-1beta (IL-1beta). Thus this study examined the effects of a cafeteria diet on IL-1beta mRNA and IL-1 receptor accessory protein (IL-1RAP) mRNA expression in rat liver and brain. Rats were fed normal rat chow or a palatable diet consisting of bread, chocolate, and shortbread cookies (cafeteria diet). After 3 days, midway between the light period of the light-dark cycle, rats were killed by decapitation. Feeding rats a cafeteria diet resulted in increased IL-1beta mRNA expression in the liver and hypothalamus compared with rats fed only the normal rat chow. In addition, cafeteria feeding decreased IL-1RAP mRNA levels in the liver and brain stem. These results indicate that feeding has direct effects on cytokine production and together with other data suggest that the increased sleep that accompanies increased feeding may be the result of increased brain IL-1beta. These results further suggest that cytokine-to-brain communication may be important in normal physiological conditions, such as feeding, as well as being important during inflammatory responses.

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Matin, Khalrul; Senpuku, Hidenobu; Hanada, Nobuhiro; Ozawa, Hidehiro; Ejiri, Sadakazu

Difficulties relating to bone regeneration that complicate immediate implant placement include buccal and/or lingual fenestrations, primary anchorage of the implants, and the need for protection from functional loading during the osseointegration period. The objective of this pilot study was to evaluate bone regeneration by recombinant human bone morphogenetic protein-2 (rhBMP-2) around immediate implants placed in maxillary sockets in rats . A total of 16 cylindric 0.8 x 1.8-mm commercially pure, solid titanium Implants were placed immediately after gentle extraction of the maxillary first molar teeth of 8 male Wistar rats . The sockets were randomly divided into 3 groups: group 1 (n = 6) received rhBMP-2 with polylactic acid/polyglycolic acid copolymer-coated gelatin sponge carrier; group 2 (n = 5) received only the carrier; and group 3 (n = 5) received no grafting materials following placement The rats were euthanized at 90 days postsurgery for microscopic analysis. In group 1, the implant body remained submerged completely, including the coronal part, which was fully covered by a significant amount (30% of total height) of regenerated cortical bone, even though the implant could easily be pulled out by a tweezer at the time of placement. Close approximation between the implant surface and regenerated bone could also be detected, indicating good bone-to-implant contact. In contrast, only peri-implant bone regeneration occurred in group 2, and an approximate 0.3-mm coronal part of the implant remained exposed. When no grafting materials were used (group 3), almost one third of the total length of the implant was exfoliated out of the socket when no grafting materials were used. Based on previous study and data from 16 sockets of the present study, it could be concluded that rhBMP-2 facilitated the regeneration of bone around immediate implants. In particular, the bone covering the coronal part could have been regenerated shortly after surgery, which helped to

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Zhan, Wei; Liao, Xin; Xie, Ru-Jia; Tian, Tian; Yu, Lei; Liu, Xing; Liu, Jing; Li, Po; Han, Bing; Yang, Ting; Zhang, Bei; Cai, Li-Jun; Li, Rui; Yang, Qin

To determine the effects ofanthocyanins from blueberries on hepatic stellate cell (HSCs-T6) and on histone acetylation during liver fibrosis induced by CCl4 in rats . Fifty male SD rats weighing 180 ± 20g were randomly placed into a control group, a hepatic fibrosis group, a blueberry treatment group, a blueberry intervention group, and a natural recovery group. After the rats were sacrificed, the livers and the liver indexes were measured, and the pathological changes were observed by HE staining and Masson staining. The blood was analyzed for the four indexes of liver fibrosis and liver function; nucleoprotein from liver tissues and karyoplasm were isolated to determine the expression of acH3K9, acH3K14, and acH3K18 by Western blotting. Compared with the lethal rate of the control group, the median lethal rate of HSCs-T6 cells treated with a the 50μmol/L concentration was 66.94% (P < 0.05). The protein expression on α-SMA, type I collagen, TIMP1 significantly decreased (P < 0.05) following treatment with 50 ug/ml of anthocyanin for 36 h; moreover, the expression of acH3K9, acH3K14 and acH3K18 modification were up-regulated (P < 0.05). Furthermore, compared with the liver in the model group, the liver in the intervention group showed the most obvious improvement (P < 0.01), and its karyoplasm had increased expression of acH3K9, acH3K14 and acH3K18 (P<0.01). Regulating histone acetylation could improve liver function and liver fibrosis indexes in rats with hepatic fibrosis. The mechanism might be related to certain genes that promote apoptosis, so as to inhibit the effect of anti hepatic fibrosis. PMID:29228569

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HANNOVER MESSE 2019, 01 - 05 April

HANNOVER MESSE 2019, 01 - 05 April
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Digital Twin

Machines today are designed with corresponding virtual representations. The physical and digital counterparts exchange data, which is constantly captured by sensors. This way, companies can detect faults earlier in the development phase—and even monitor machinery and components after distribution.

A perfect look-alike, just in case

Greater product diversity, higher quality and lower production costs: Digital Twins are revolutionizing how industry works. Virtual twins accompany a physical product from the initial conceptualization and the design process right through production and updates - helping digital machine construction run better.

3D models instead of prototypes

Digital Twins are digital representations of physical machines. In industry, they are used to optimize product design and ensure error-free operation. They are formed on the basis of a high-precision 3D CAD model that has been assigned all the properties and functions of the planned product - from its materials and sensoring systems to the movement and dynamics of the real machine. This is an important step towards identifying malfunctions early and resolving them before the start of production - and eliminating the need for development of a costly prototype.

Constant exchange of data

The twins are constantly in connection with one another - even after production and sale of the physical product. The real machine is outfitted with sensors that send status data to its virtual reproduction on a constant basis. A requirement management system functions as a digital requirements library, gathering the incoming data and comparing it against the specifications by which the product was created.

If a discrepancy is detected, then engineers can work on potential solutions directly on the digital twin - after which the real machine can then be updated to resolve the problem as quickly as possibly.

IT security for digital twins

To ensure the security of the Digital Twins, a variety of enhanced security measures from the IT realm are needed in industry. Digital industry systems are an especially common target for malicious software, spread through the internet, corporate intranets or external hardware. The concept of "industrial security" is thus not just focused on physical securing of devices through alarm systems and access codes, but also the use of firewalls in corporate networks and walling off of external electronic interfaces. To protect industrial systems against cyber-attacks, manufacturers such as Siemens and Genua Solutions offer solutions to be deployed at all levels to ensure not only system and network security, but also system integrity.

In the future, all stakeholders will be networked: suppliers, producers and customers. The focus now must be put on building a strong network between machine builders, electrical engineers and IT. For Nice Tom Ford Leather ChainLink Sandals Eastbay Online Outlet Best Seller Clearance With Mastercard Clearance Reliable u2Cp7
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Digital Twin

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November 14 1950 horoscope and zodiac sign meanings.

The following report will help you understand better the influence of astrology and birthday meanings for a person born under November 14 1950 horoscope. The presentation consists in a few Scorpio sign trademarks, Chinese zodiac animal traits, best love matches and incompatibilities, famous people born under same zodiac animal and a remarkable analysis of personality descriptors.

Horoscope and zodiac sign meanings

The zodiac sign linked with this birthday has several eloquent meanings we should be starting with:

Birthday characteristics interpretation

As each birthday has its influence, so November 14, 1950 carries several features of the personality and the evolution of someone born on this day. In a subjective manner are selected and evaluated 15 descriptors showing possible qualities or flaws of a person having this birthday, together with a chart that displays possible horoscope lucky features in life.

Horoscope personality descriptors chart

Some resemblance!
Sometimes descriptive!
Little to few resemblance!
Very good resemblance!
Rarely descriptive!
No resemblance!
Little resemblance!
Good description!
Quite descriptive!
Rarely descriptive!
Great resemblance!
Sometimes descriptive!
Completely descriptive!
Quite descriptive!
No resemblance!

Horoscope lucky features chart

Little to no luck!
Rarely lucky!
Little luck!
Pretty lucky!
Good luck!

November 14 1950 health astrology

People born under Scorpio horoscope have a general sensibility in the area of the pelvis and to the components of the reproductive system. This means people born on this date are predisposed to a series of illnesses and ailments in connection to these areas. Please take account that does not exclude the possibility for a Scorpio to suffer from other health issues. Below you can find a few health problems someone born under this horoscope sign may suffer from:

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Doug Drinkwater is the Contributing Editor at Internet of Business. An experienced technology journalist and editor with a passion for emerging technology, his work has previously appeared on a number of well-regarded IT titles, including, CSO Online, International Business Times, Macworld, Mashable, PCWorld, SC Magazine and The Gadget Show Magazine.